Methylomic investigation of problematic adolescent cannabis use and its negative mental health consequences
Objective The impact of adolescent cannabis use is a pressing public health question owing
to the high rates of use and links to negative outcomes. This study considered the …
to the high rates of use and links to negative outcomes. This study considered the …
[HTML][HTML] DNA methylation as a therapeutic and diagnostic target in major depressive disorder
E Lax - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Major Depressive Disorder (MDD) is a widespread debilitating neuropsychiatric disorder.
While a broad range of drugs to treat MDD are available, a large portion of the patients fail to …
While a broad range of drugs to treat MDD are available, a large portion of the patients fail to …
Independent methylome-wide association studies of schizophrenia detect consistent case–control differences
Methylome-wide association studies (MWASs) are promising complements to sequence
variation studies. We used existing sequencing-based methylation data, which assayed the …
variation studies. We used existing sequencing-based methylation data, which assayed the …
[HTML][HTML] Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information
H Gedik, TH Nguyen, RE Peterson… - Frontiers in …, 2023 - frontiersin.org
Neuropsychiatric and substance use disorders (NPSUDs) have a complex etiology that
includes environmental and polygenic risk factors with significant cross-trait genetic …
includes environmental and polygenic risk factors with significant cross-trait genetic …
[HTML][HTML] Using openly accessible resources to strengthen causal inference in epigenetic epidemiology of neurodevelopment and mental health
The recent focus on the role of epigenetic mechanisms in mental health has led to several
studies examining the association of epigenetic processes with psychiatric conditions and …
studies examining the association of epigenetic processes with psychiatric conditions and …
Interactions of childhood maltreatment and genetic variations in adult depression: A systematic review
Background Childhood maltreatment (CM) significantly increases the risk of adulthood
psychopathology. Interplay between susceptible genetic variations and CM contributes to …
psychopathology. Interplay between susceptible genetic variations and CM contributes to …
Neuroimaging and epigenetic analysis reveal novel epigenetic loci in major depressive disorder
BackgroundEpigenetic modifications, such as DNA methylation, contribute to the
pathophysiology of major depressive disorder (MDD). This study aimed to identify novel …
pathophysiology of major depressive disorder (MDD). This study aimed to identify novel …
[HTML][HTML] Advances in depression research: second special issue, 2020, with highlights on biological mechanisms, clinical features, co-morbidity, genetics, imaging …
The current speed of progress in depression research is simply remarkable. We have
therefore been able to create a second special issue of Molecular Psychiatry, 2020, focused …
therefore been able to create a second special issue of Molecular Psychiatry, 2020, focused …
[HTML][HTML] No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state
Background Methylation of serotonin-related genes has been proposed as a plausible gene-
by-environment link which may mediate environmental stress, depressive and anxiety …
by-environment link which may mediate environmental stress, depressive and anxiety …
[HTML][HTML] DNA methylation of the KLK8 gene in depression symptomatology
A Starnawska, L Bukowski, A Chernomorchenko… - Clinical …, 2021 - Springer
Background Depression is a common, complex, and debilitating mental disorder estimated
to be under-diagnosed and insufficiently treated in society. Liability to depression is …
to be under-diagnosed and insufficiently treated in society. Liability to depression is …