Copper and Copper Complexes in Tumor Therapy

Y Wang, T Tang, Y Yuan, N Li, X Wang… - ChemMedChem, 2024 - Wiley Online Library
Copper (Cu), a crucial trace element in physiological processes, has garnered significant
interest for its involvement in cancer progression and potential therapeutic applications. The …

Phenanthroline and Schiff Base associated Cu (II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity

V Kumar, R Kataria - Journal of Inorganic Biochemistry, 2023 - Elsevier
As an inherent metal ion, copper has been the subject of investigation for developing a
novel antitumoral compound that exhibits fewer adverse effects. Copper serves as a cofactor …

Exploring the potential of tamoxifen-based copper (ii) dichloride in breast cancer therapy

A Kazimir, B Schwarze, P Lönnecke, S Jelača… - RSC Medicinal …, 2023 - pubs.rsc.org
For decades, tamoxifen-based hormone therapy has effectively addressed oestrogen
receptor positive (ER+) luminal A breast cancer. Nonetheless, the emergence of tamoxifen …

Experimental and Computational Studies on the Interaction of DNA with Hesperetin Schiff Base CuII Complexes

F Pisanu, A Sykula, G Sciortino, F Maseras… - International journal of …, 2024 - mdpi.com
The interactions with calf thymus DNA (CT-DNA) of three Schiff bases formed by the
condensation of hesperetin with benzohydrazide (HHSB or L1H3), isoniazid (HIN or L2H3) …

The Therapeutic Potential in Cancer of Terpyridine‐Based Metal Complexes Featuring Group 11 Elements

M Gil‐Moles, M Concepción Gimeno - ChemMedChem, 2024 - Wiley Online Library
Terpyridine‐based complexes with group 11 metals emerge as potent metallodrugs in
cancer therapy. This comprehensive review focuses on the current landscape of anticancer …

Cancer stem cell activity of copper (ii)-terpyridine complexes with aryl sulfonamide groups

K Singh, J Northcote-Smith, K Singh… - Dalton …, 2023 - pubs.rsc.org
Copper (II)-terpyridine complexes are endowed with the ability to generate reactive oxygen
species (ROS) and induce cancer cell death. Here we report the synthesis, characterisation …

Copper (II) Complexes with 2, 2′: 6′, 2 ″-Terpyridine Derivatives Displaying Dimeric Dichloro− μ–Bridged Crystal Structure: Biological Activities from 2D and 3D …

K Choroba, B Machura, K Erfurt… - Journal of Medicinal …, 2024 - ACS Publications
Eight 2, 2′: 6′, 2 ″-terpyridines, substituted at the 4′-position with aromatic groups
featuring variations in π-conjugation, ring size, heteroatoms, and methoxy groups, were …

[HTML][HTML] Structural and solution speciation studies on selected [Cu (NN)(OO)] complexes and an investigation of their biomimetic activity, ROS generation and their …

H Jenkins, L MacLean, S McClean, G Cooke… - Journal of Inorganic …, 2023 - Elsevier
Reactive oxygen species (ROS) generation with subsequent DNA damage is one of the
principle mechanisms of action assigned to copper-based anticancer complexes. The …

Highly cytotoxic Cu (ii) terpyridine complexes as chemotherapeutic agents

K Ni, N Montesdeoca, J Karges - Dalton Transactions, 2024 - pubs.rsc.org
Cancer is considered as the biggest medicinal challenge worldwide. During a typical
treatment, the tumorous tissue is removed in a surgical procedure and the patient further …

Photochemotherapeutic Properties of Cu (II) Complexes of L‐Lysine and L‐Arginine Appended to Anthracene

A Banaspati, MK Raza, TK Goswami - ChemistrySelect, 2023 - Wiley Online Library
Cu (II) complexes of positively charged amino acids L–Lysine and L‐Arginine appended to
an anthracene unit and phenanthroline bases, namely [Cu (Anth‐Lys)(L)(ClO4)](1, 2) and …