The four major classes of protease enzymes1-4 (aspartic, serine, cysteine, and metallo)
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis …

This review describes the clinical status (based on available information) of experimental
drugs that inhibit enzymes called proteases, or more precisely a sub-class of proteases …

Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are the major hydrolytic
enzymes responsible for the metabolism of numerous therapeutic agents as well as …

We reported a novel two-step stereoselective synthesis of functionalized pyrrolidines from
homopropargylic sulfonamides and nucleophiles via an isolable N, O-acetal intermediates …

Publisher Summary Angiotensin-converting enzyme (ACE) inhibitors were first studied
clinically in the 1970s. ACE inhibitors were discovered by taking advantage of previous …

Trandolapril (TLP), is an antihypertensive agent, administered orally. It is having low oral
bioavailability (4–9%) due to poor aqueous solubility, it undergoes CYP3A4 mediated …

Type 2 diabetes mellitus and heart failure are closely related, patients with type 2 diabetes
mellitus have a higher risk of developing heart failure, and those with heart failure are at …

A TMSOTf mediated 5/6-endo-dig reductive hydroamination cascade on internal
alkynylamines gave expedient, stereoselective access to pyrrolidine and piperidine …

In this article, 2 leading physicians debate the strength of outcome data on the efficacy of
angiotensin-converting enzyme (ACE) inhibitors versus angiotensin II receptor blockers …

Trandolapril/verapamil sustained release (SR)[Tarka®] is an oral, fixed-dose combination of
the ACE inhibitor trandolapril and the SR formulation of the phenylalkylamine calcium …