Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Endothelial dysfunction in hypertension: current concepts and clinical implications

G Gallo, M Volpe, C Savoia - Frontiers in medicine, 2022 - frontiersin.org
Endothelium plays a fundamental role in the cardiovascular system, forming an interface
between blood and adjacent tissues by regulating the vascular tone through the synthesis of …

Mechanisms of oxidized LDL-mediated endothelial dysfunction and its consequences for the development of atherosclerosis

H Jiang, Y Zhou, SM Nabavi, A Sahebkar… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is an immuno-metabolic disease involving chronic inflammation, oxidative
stress, epigenetics, and metabolic dysfunction. There is compelling evidence suggesting …

Hypertension, neurovascular dysfunction, and cognitive impairment

MM Santisteban, C Iadecola, D Carnevale - Hypertension, 2023 - Am Heart Assoc
Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Resveratrol in treating diabetes and its cardiovascular complications: a review of its mechanisms of action

M Su, W Zhao, S Xu, J Weng - Antioxidants, 2022 - mdpi.com
Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. High
morbidity and mortality caused by DM are closely linked to its complications in multiple …

Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment

SR Botts, JE Fish, KL Howe - Frontiers in pharmacology, 2021 - frontiersin.org
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

Resveratrol and endothelial function: A literature review

N Parsamanesh, A Asghari, S Sardari… - Pharmacological …, 2021 - Elsevier
Endothelial dysfunction is a major contributing factor to diseases such as atherosclerosis,
diabetes mellitus, obesity, hypertension, acute lung injury, preeclampsia, among others …

Deletion of BACH1 attenuates atherosclerosis by reducing endothelial inflammation

M Jia, Q Li, J Guo, W Shi, L Zhu, Y Huang, Y Li… - Circulation …, 2022 - Am Heart Assoc
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed
endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …