Towards a biologically annotated brain connectome

V Bazinet, JY Hansen, B Misic - Nature reviews neuroscience, 2023 - nature.com
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …

[HTML][HTML] Toward best practices for imaging transcriptomics of the human brain

A Arnatkeviciute, RD Markello, BD Fulcher, B Misic… - Biological …, 2023 - Elsevier
Modern brainwide transcriptional atlases provide unprecedented opportunities for
investigating the molecular correlates of brain organization, as quantified using noninvasive …

Neuromaps: structural and functional interpretation of brain maps

RD Markello, JY Hansen, ZQ Liu, V Bazinet, G Shafiei… - Nature …, 2022 - nature.com
Imaging technologies are increasingly used to generate high-resolution reference maps of
brain structure and function. Comparing experimentally generated maps to these reference …

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

JY Hansen, G Shafiei, JW Vogel, K Smart… - Nature …, 2022 - nature.com
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

[HTML][HTML] BrainStat: A toolbox for brain-wide statistics and multimodal feature associations

S Larivière, Ş Bayrak, RV de Wael, O Benkarim… - Neuroimage, 2023 - Elsevier
Abstract Analysis and interpretation of neuroimaging datasets has become a
multidisciplinary endeavor, relying not only on statistical methods, but increasingly on …

An energy costly architecture of neuromodulators for human brain evolution and cognition

G Castrillon, S Epp, A Bose, L Fraticelli, A Hechler… - Science …, 2023 - science.org
In comparison to other species, the human brain exhibits one of the highest energy
demands relative to body metabolism. It remains unclear whether this heightened energy …

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

S Larivière, J Royer, R Rodríguez-Cruces… - Nature …, 2022 - nature.com
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …

Whole-brain comparison of rodent and human brains using spatial transcriptomics

A Beauchamp, Y Yee, BC Darwin, A Raznahan… - Elife, 2022 - elifesciences.org
The ever-increasing use of mouse models in preclinical neuroscience research calls for an
improvement in the methods used to translate findings between mouse and human brains …

Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease

JY Hansen, G Shafiei, K Voigt, EX Liang, SML Cox… - PLoS …, 2023 - journals.plos.org
The brain is composed of disparate neural populations that communicate and interact with
one another. Although fiber bundles, similarities in molecular architecture, and synchronized …

Trips and neurotransmitters: Discovering principled patterns across 6850 hallucinogenic experiences

G Ballentine, SF Friedman, D Bzdok - Science advances, 2022 - science.org
Psychedelics probably alter states of consciousness by disrupting how the higher
association cortex governs bottom-up sensory signals. Individual hallucinogenic drugs are …