Regional homogeneity alterations in patients with functional constipation and their associations with gene expression profiles

W Cai, H Tian, P Sun, T Hua, J Gong, R Zhang… - Cerebral …, 2024 - academic.oup.com
Functional constipation, a highly prevalent functional gastrointestinal disorder, often
accompanies by mental and psychological disorders. Previous neuroimaging studies have …

Atypical dynamic network reconfiguration and genetic mechanisms in patients with major depressive disorder

H Xiao, D Tang, C Zheng, Z Yang, W Zhao… - Progress in Neuro …, 2024 - Elsevier
Background Brain dynamics underlie complex forms of flexible cognition or the ability to shift
between different mental modes. However, the precise dynamic reconfiguration based on …

[HTML][HTML] Integrating neuroimaging and gene expression data using the imaging transcriptomics toolbox

A Giacomel, D Martins, M Frigo, F Turkheimer… - STAR protocols, 2022 - Elsevier
The integration of neuroimaging and transcriptomics data, Imaging Transcriptomics, is
becoming increasingly popular but standardized workflows for its implementation are still …

Transcriptomic contributions to a modern cytoarchitectonic parcellation of the human cerebral cortex

L King, KS Weiner - Brain Structure and Function, 2024 - Springer
Transcriptomic contributions to the anatomical, functional, and network layout of the human
cerebral cortex (HCC) have become a major interest in cognitive and systems neuroscience …

[HTML][HTML] General anaesthesia reduces the uniqueness of brain connectivity across individuals and across species

AI Luppi, D Golkowski, A Ranft, R Ilg, D Jordan… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The human brain is characterised by idiosyncratic patterns of spontaneous thought,
rendering each brain uniquely identifiable from its neural activity. However, deep general …

[HTML][HTML] Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia

R Dear, K Wagstyl, J Seidlitz, RD Markello… - Nature …, 2024 - nature.com
Human brain organization involves the coordinated expression of thousands of genes. For
example, the first principal component (C1) of cortical transcription identifies a hierarchy …

[HTML][HTML] Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia

Y Han, Y Yang, Z Zhou, X Jin, H Shi, M Shao… - NeuroImage: Clinical, 2023 - Elsevier
Abstract Background and Hypothesis Schizophrenia (SZ) patients display significant
structural brain abnormalities; nevertheless, the genetic mechanisms regulating cortical …

[HTML][HTML] C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types

IJ Broce, DW Sirkis, RM Nillo, LW Bonham… - Frontiers in …, 2024 - frontiersin.org
Introduction A hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open
reading frame 72 (C9orf72) is recognized as the most common genetic cause of …

Multimodal, multiscale connectivity blueprints of the cerebral cortex

JY Hansen, G Shafiei, K Voigt, EX Liang, SML Cox… - bioRxiv, 2022 - biorxiv.org
The brain is composed of disparate neural populations that communicate and interact with
one another. Although fiber bundles, similarities in molecular architecture, and synchronized …

[HTML][HTML] Modeling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis

S Pandya, PD Maia, B Freeze, RAL Menke, K Talbot… - Neuroimage, 2022 - Elsevier
The neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is characterized by the
progressive loss of upper and lower motor neurons, with pathological involvement of …