New perspectives on antimicrobial agents: molnupiravir and nirmatrelvir/ritonavir for treatment of COVID-19

RL Atmar, N Finch - Antimicrobial agents and chemotherapy, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged to cause
pandemic respiratory disease in the past 2 years, leading to significant worldwide morbidity …

Current effective therapeutics in management of COVID-19

K Atluri, I Aimlin, S Arora - Journal of Clinical Medicine, 2022 - mdpi.com
The current pandemic due to the SARS-CoV-2 virus has caused irreparable damage
globally. High importance is placed on defining current therapeutics for Coronavirus …

Monoclonal antibody therapies in the management of SARS-CoV-2 infection

E Miguez-Rey, D Choi, S Kim, S Yoon… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction Neutralizing antibodies (NAbs) that target key domains of the spike
protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have …

Molnupiravir for treatment of adults with mild or moderate COVID-19: a systematic review and meta-analysis of randomized controlled trials

Y Gao, M Liu, Z Li, J Xu, J Zhang, J Tian - Clinical Microbiology and …, 2023 - Elsevier
Background The effects of molnupiravir in treating patients with non-severe COVID-19
remain uncertain. Objectives To evaluate the efficacy and safety of molnupiravir in adult …

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis

JJ Malin, S Weibel, H Gruell… - Journal of …, 2023 - academic.oup.com
Background The role of molnupiravir for coronavirus disease 2019 (COVID-19) treatment is
unclear. Methods We conducted a systematic review until 1 November 2022 searching for …

Efficacy and safety of molnupiravir treatment for COVID-19: a systematic review and meta-analysis of randomized controlled trials

F Tian, Q Feng, Z Chen - International Journal of Antimicrobial Agents, 2023 - Elsevier
Introduction There are currently some differences in the research results of molnupiravir.
This study aimed to evaluate the efficacy and safety of molnupiravir in the treatment of …

Evolutionary safety of lethal mutagenesis driven by antiviral treatment

G Lobinska, Y Pilpel, MA Nowak - PLoS biology, 2023 - journals.plos.org
Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral
mutation rate causing lethal mutagenesis of the virus. Their mutagenic capacity, however …

Outpatient treatment of confirmed COVID-19: a living, rapid review for the American College of Physicians

I Sommer, A Dobrescu, D Ledinger, I Moser… - Annals of internal …, 2023 - acpjournals.org
An updated version of this article was published on 19 September 2023. This article has
been corrected. The original version of the article and supplement (PDF) is appended to this …

Molnupiravir's authorisation was premature

JM Brophy - bmj, 2022 - bmj.com
On 1 October 2021 Merck issued a press release 1 reporting an interim analysis of Move-
Out, a phase 3 randomised placebo controlled trial in unvaccinated adults with confirmed …

Clinical efficacy and safety of molnupiravir for nonhospitalized and hospitalized patients with COVID‐19: a systematic review and meta‐analysis of randomized control …

PY Huang, TH Liu, JY Wu, YW Tsai… - Journal of Medical …, 2023 - Wiley Online Library
The efficacy of molnupiravir in treating patients with coronavirus disease 2019 (COVID‐19)
has been inconsistent across randomized controlled trials (RCTs). Thus, this meta‐analysis …