Glycosaminoglycans: what remains to be deciphered?

S Perez, O Makshakova, J Angulo, E Bedini, A Bisio… - Jacs Au, 2023 - ACS Publications
Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …

Correlation between hepatocyte growth factor (HGF) with D-dimer and interleukin-6 as prognostic markers of coagulation and inflammation in long COVID-19 …

B Zaira, T Yulianti, J Levita - Current Issues in Molecular Biology, 2023 - mdpi.com
In general, an individual who experiences the symptoms of Severe Acute Respiratory
Syndrome Coronavirus 2 or SARS-CoV-2 infection is declared as recovered after 2 weeks …

Production of different molecular weight glycosaminoglycans with microbial cell factories

D Wang, L Hu, R Xu, W Zhang, H Xiong, Y Wang… - Enzyme and Microbial …, 2023 - Elsevier
Glycosaminoglycans (GAGs) are naturally occurring acidic polysaccharides with wide
applications in pharmaceuticals, cosmetics, and health foods. The diverse biological …

The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review

A Frackiewicz, B Kalaska, J Miklosz, A Mogielnicki - Thrombosis Journal, 2023 - Springer
The assessment of hemostasis is necessary to make suitable decisions on the management
of patients with thrombotic disorders. In some clinical situations, for example, during …

The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment

S Timm, M Lettau, J Hegermann, ML Rocha… - Histochemistry and Cell …, 2023 - Springer
Recent investigations analyzed in depth the biochemical and biophysical properties of the
endothelial glycocalyx. In comparison, this complex cell-covering structure is largely …

Extending the enzymatic toolbox for heparosan polymerization, depolymerization, and detection

M Sulewska, M Berger, M Damerow, D Schwarzer… - Carbohydrate …, 2023 - Elsevier
Heparosan is an acidic polysaccharide expressed as a capsule polymer by pathogenic and
commensal bacteria, eg by E. coli K5. As a precursor in the biosynthesis of heparan sulfate …

[HTML][HTML] The pro-healing effects of heparan sulfate and growth factors are enhanced by the heparinase enzyme: New association for skin wound healing treatment

R Belvedere, N Novizio, M Palazzo… - European Journal of …, 2023 - Elsevier
Effective treatment strategies for skin wound repair are the focus of numerous studies. New
pharmacological approaches appear necessary to guarantee a correct and healthy tissue …

[HTML][HTML] Flavonoids extract from Rosa roxburghii fruit ameliorates carrageenan-induced thrombosis in mice

X Pu, Y Tao, J Lou, G Lu, H Xu, S Tan, G Xie - Journal of Functional Foods, 2023 - Elsevier
The fruits of Rosa roxburghii contain a high amount of flavonoids. We conducted a study
using a carrageenan-induced thrombus model to investigate how Rosa roxburghii fruit …

Facile chemoenzymatic synthesis of unmodified anticoagulant ultra-low molecular weight heparin

G Zhang, K Yang, L Wang, Y Cheng… - Organic & Biomolecular …, 2022 - pubs.rsc.org
A chemoenzymatic approach, mimicking the biosynthetic pathway of heparin and heparan
sulfate (HS), has been well developed to prepare a series of structurally well-defined …

Characterization of maltose‐binding protein–fused heparinases with enhanced thermostability by application of rigid and flexible linkers

X Wu, Z Yun, N Su, L Zhao, H Zhang… - Biotechnology and …, 2024 - Wiley Online Library
Heparinases, including heparinases I–III (HepI, HepII, and HepIII, respectively), are
important tools for producing low‐molecular‐weight heparin, an improved anticoagulant …