The host immune response in respiratory virus infection: balancing virus clearance and immunopathology

AH Newton, A Cardani, TJ Braciale - Seminars in immunopathology, 2016 - Springer
The respiratory tract is constantly exposed to the external environment, and therefore, must
be equipped to respond to and eliminate pathogens. Viral clearance and resolution of …

The mechanism behind influenza virus cytokine storm

Y Gu, X Zuo, S Zhang, Z Ouyang, S Jiang, F Wang… - Viruses, 2021 - mdpi.com
Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-
cell communication and viral clearance in the immune system, but excessive cytokines can …

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

AC Ferreira, VC Soares… - Cell death …, 2021 - nature.com
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
associated with leukopenia and uncontrolled inflammatory response in critically ill patients …

Controversies about COVID-19 and anticancer treatment with immune checkpoint inhibitors

M Bersanelli - Immunotherapy, 2020 - Future Medicine
Conclusion Clinical decisions about cancer patients deserving immunotherapy in the current
context of the COVID-19 pandemic should be characterized by separated reflections …

Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway

AR Daamen, P Bachali, KA Owen, KM Kingsmore… - Scientific reports, 2021 - nature.com
SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-
19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated …

New fronts emerge in the influenza cytokine storm

XJ Guo, PG Thomas - Seminars in immunopathology, 2017 - Springer
Influenza virus is a significant pathogen in humans and animals with the ability to cause
extensive morbidity and mortality. Exuberant immune responses induced following infection …

Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection

BM Tang, M Shojaei, S Teoh, A Meyers, J Ho… - Nature …, 2019 - nature.com
Severe influenza infection has no effective treatment available. One of the key barriers to
developing host-directed therapy is a lack of reliable prognostic factors needed to guide …

[HTML][HTML] Feasibility of a 5G-based robot-assisted remote ultrasound system for cardiopulmonary assessment of patients with coronavirus disease 2019

R Ye, X Zhou, F Shao, L Xiong, J Hong, H Huang… - Chest, 2021 - Elsevier
Background Traditional methods for cardiopulmonary assessment of patients with
coronavirus disease 2019 (COVID-19) pose risks to both patients and examiners. This …

Role of the innate cytokine storm induced by the influenza A virus

Y Gu, ACY Hsu, Z Pang, H Pan, X Zuo, G Wang… - Viral …, 2019 - liebertpub.com
Influenza A viruses (IAVs) can be classified into dozens of subtypes based on their
hemagglutinin (HA) and neuraminidase (NA) proteins. To date, 18 HA subtypes and 11 NA …

PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection

S Huang, B Zhu, IS Cheon, NP Goplen, L Jiang… - Journal of …, 2019 - Am Soc Microbiol
Alveolar macrophages (AM) play pivotal roles in modulating host defense, pulmonary
inflammation, and tissue injury following respiratory viral infections. However, the …