Up to 15% of the population have mild to moderate chronic hypomagnesemia, which is
associated with type 2 diabetes mellitus, hypertension, metabolic syndrome, and chronic …

CKD represents a major health burden linked with higher risk for cardiovascular disease
and premature mortality. UMOD, encoding uromodulin, is implicated in a spectrum from rare …

Abstract Background Within European traditional phytotherapy, extracts from different herbal
plants are used for prevention and therapy of uncomplicated urinary tract infections and for …

Introduction Vancomycin nephrotoxicity is frequent and may be due to drug-induced acute
tubular necrosis (ATN) or tubulointerstitial nephritis (TIN). Vancomycin-associated tubular …

Background: The association of uromodulin and hypertension has been observed in clinical
studies, but not proven by a causal relationship. We conducted a two-sample Mendelian …

Hypertension is a significant risk factor for cardiovascular disease and mortality worldwide.
The kidney is a major regulator of blood pressure and electrolyte homeostasis, with …

Background Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI.
However, currently available publications showed inconsistent results. We designed this …

Cranberry is a well-known functional food, but the compounds directly responsible for many
of its reported health benefits remain unidentified. Complex carbohydrates, specifically …

Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick
ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the …

Introduction: Noninvasive biomarkers that reflect tubular health and allow early recognition
of accelerated graft fibrosis development are warranted. Serum uromodulin (sUmod) and …