Objectives Uromodulin has been associated with arterial hypertension in genome-wide
association studies, but data from clinical and preclinical studies are inconsistent. We here …

Introduction Acute kidney injury (AKI) defined by a substantial decrease in kidney function
within hours to days and is often irreversible with higher risk to chronic kidney disease …

Uromodulin, also referred to as Tamm Horsfall protein (THP), is a renal protein exclusively
synthesized by the kidneys and represents the predominant urinary protein under normal …

The epithelial cells that line the kidneys and lower urinary tract are exposed to mechanical
forces including shear stress and wall tension; however, the mechanosensors that detect …

Uromodulin is a nephrospecific protein that is most common in normal urine. And although it
has been known for more than 70 years, the function of uromodulin remains unclear …

JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a life-
threatening brain disease in immunocompromised patients. Inherited and acquired T cell …

Genetic variants in UMOD associate with kidney function and hypertension. These
phenotypes are also linked to sex-related differences and impairment in cognitive and …

UMOD is the first identified and the most commonly mutated gene that causes autosomal
dominant tubulointerstitial kidney disease (ADTKD). Recent studies have shown that ADTKD …

Background Hypertension is one of the major etiologies that cause chronic kidney disease
(CKD) and can exacerbate kidney dysfunction. Zinc is an essential trace element playing a …

The with-no-lysine (WNK) kinase family, comprising four serine-threonine protein kinases
(WNK1-4), were first linked to hypertension due to their mutations in association with …