Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

M Sadarangani, A Marchant… - Nature Reviews …, 2021 - nature.com
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …

Progress and prospects on vaccine development against SARS-CoV-2

J Zhang, H Zeng, J Gu, H Li, L Zheng, Q Zou - Vaccines, 2020 - mdpi.com
In December 2019, the outbreak of pneumonia caused by a novel coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a serious pandemic in China …

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

G Cerutti, Y Guo, T Zhou, J Gorman, M Lee, M Rapp… - Cell host & …, 2021 - cell.com
Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally
target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral …

A universal design of betacoronavirus vaccines against COVID-19, MERS, and SARS

L Dai, T Zheng, K Xu, Y Han, L Xu, E Huang, Y An… - Cell, 2020 - cell.com
Vaccines are urgently needed to control the ongoing pandemic COVID-19 and previously
emerging MERS/SARS caused by coronavirus (CoV) infections. The CoV spike receptor …

[HTML][HTML] Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus

B Korber, WM Fischer, S Gnanakaran, H Yoon… - Cell, 2020 - cell.com
A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become
the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies …

Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

KS Corbett, B Flynn, KE Foulds… - … England Journal of …, 2020 - Mass Medical Soc
Background Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed.
The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on …

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

M McCallum, A De Marco, FA Lempp, MA Tortorici… - Cell, 2021 - cell.com
Summary The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-
binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient …

An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies

S Jiang, L Du, Z Shi - Emerging microbes & infections, 2020 - Taylor & Francis
In December of 2019, an outbreak of pneumonia caused by an unknown aetiology occurred
in Wuhan, China and most patients were linked to a single seafood market, which reportedly …

Vaccination in patients with kidney failure: lessons from COVID-19

N Babel, C Hugo, TH Westhoff - Nature Reviews Nephrology, 2022 - nature.com
Infection is the second leading cause of death in patients with chronic kidney disease (CKD).
Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize …

Microstructure, pathophysiology, and potential therapeutics of COVID‐19: a comprehensive review

SP Singh, M Pritam, B Pandey… - Journal of medical …, 2021 - Wiley Online Library
There have been over seven million cases and almost 413 372 deaths globally due to the
novel coronavirus (2019‐nCoV) associated disease COVID‐19, as of 11 June 2020 …