Integrative methods for analyzing big data in precision medicine
We provide an overview of recent developments in big data analyses in the context of
precision medicine and health informatics. With the advance in technologies capturing …
precision medicine and health informatics. With the advance in technologies capturing …
Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders
In a research environment dominated by reductionist approaches to brain disease
mechanisms, gene network analysis provides a complementary framework in which to tackle …
mechanisms, gene network analysis provides a complementary framework in which to tackle …
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain
To provide a temporal framework for the genoarchitecture of brain development, we
generated in situ hybridization data for embryonic and postnatal mouse brain at seven …
generated in situ hybridization data for embryonic and postnatal mouse brain at seven …
The Botany Array Resource: e‐Northerns, expression angling, and promoter analyses
Summary The Botany Array Resource provides the means for obtaining and archiving
microarray data for Arabidopsis thaliana as well as biologist‐friendly tools for viewing and …
microarray data for Arabidopsis thaliana as well as biologist‐friendly tools for viewing and …
Fruit weight is controlled by Cell Size Regulator encoding a novel protein that is expressed in maturing tomato fruits
QI Mu, Z Huang, M Chakrabarti, E Illa-Berenguer… - PLoS …, 2017 - journals.plos.org
Increases in fruit weight of cultivated vegetables and fruits accompanied the domestication
of these crops. Here we report on the positional cloning of a quantitative trait locus (QTL) …
of these crops. Here we report on the positional cloning of a quantitative trait locus (QTL) …
[PDF][PDF] Mining coherent dense subgraphs across massive biological networks for functional discovery
Motivation: The rapid accumulation of biological network data translates into an urgent need
for computational methods for graph pattern mining. One important problem is to identify …
for computational methods for graph pattern mining. One important problem is to identify …
[HTML][HTML] Coexpression, coregulation, and cofunctionality of neighboring genes in eukaryotic genomes
P Michalak - Genomics, 2008 - Elsevier
Accumulating evidence indicates that gene order in eukaryotic genomes is not completely
random and that genes with similar expression levels tend to be clustered within the same …
random and that genes with similar expression levels tend to be clustered within the same …
Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus
DM Gardiner, BJ Howlett - FEMS microbiology letters, 2005 - academic.oup.com
Gliotoxin is a secondary metabolite produced by several fungi including the opportunistic
animal pathogen Aspergillus fumigatus. It is a member of the epipolythiodioxopiperazine …
animal pathogen Aspergillus fumigatus. It is a member of the epipolythiodioxopiperazine …
Emergence of co-expression in gene regulatory networks
Transcriptomes are known to organize themselves into gene co-expression clusters or
modules where groups of genes display distinct patterns of coordinated or synchronous …
modules where groups of genes display distinct patterns of coordinated or synchronous …
Integration of 'omics' data in aging research: from biomarkers to systems biology
Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …