The transcriptional upregulation of oncogenes is a driving force behind the progression of
many tumours. However, until a decade ago, the concept of 'switching off'these oncogenic …

Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Environmental epigenetics describes how environmental factors affect cellular epigenetics
and, hence, human health. Epigenetic marks alter the spatial conformation of chromatin to …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …