Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's
disease between the men and women at later age. However it is important to know that sex …

Abstract The Testosterone Trials (TTrials) were a coordinated set of seven placebo-
controlled, double-blind trials in 788 men with a mean age of 72 years to determine the …

Abstract Objective To update the “Testosterone Therapy in Men With Androgen Deficiency
Syndromes” guideline published in 2010. Participants The participants include an Endocrine …

Background Serum testosterone concentrations decrease as men age, but benefits of
raising testosterone levels in older men have not been established. Methods We assigned …

Background Current approaches to diagnosing testosterone deficiency do not consider the
physiological consequences of various testosterone levels or whether deficiencies of …

Objective: Our objective was to update the guidelines for the evaluation and treatment of
androgen deficiency syndromes in adult men published previously in 2006. Participants …

Background The association between aging-related testosterone deficiency and late-onset
hypogonadism in men remains a controversial concept. We sought evidence-based criteria …

Background Testosterone therapy is increasingly promoted. No randomized placebo-
controlled trial has been implemented to assess the effect of testosterone therapy on …

Recent research suggests that increased adiposity is associated with poor cognitive
performance, independently of associated medical conditions. The evidence regarding this …

Context: Low testosterone levels have been associated with outcomes that reduce survival
in men. Objective: Our objective was to perform a systematic review and meta-analysis of …