The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …

Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process
catalyzed by a specialized membrane-fusion protein expressed on their surface. This review …

Structure determination of the HIV‐1 envelope glycoprotein (Env) presented a number of
challenges, but several high‐resolution structures have now become available. In 2013 …

Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are
prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary …

We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …

A major advance in the search for an HIV vaccine has been the development of a near-
native Envelope trimer (BG505 SOSIP. 664) that can induce robust autologous Tier 2 …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

The Lassa virus is endemic in parts of West Africa, and it causes hemorrhagic fever with high
mortality. The development of a recombinant protein vaccine has been hampered by the …

A range of current candidate AIDS vaccine regimens are focused on generating protective
HIV-neutralizing Ab responses. Many of these efforts rely on the rhesus macaque animal …

Hepatitis C virus (HCV) infection affects approximately 58 million people and causes~
300,000 deaths yearly. The only target for HCV neutralizing antibodies is the highly …