[HTML][HTML] Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers
MG Pauthner, JP Nkolola, C Havenar-Daughton… - Immunity, 2019 - cell.com
Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from
hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge …
hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge …
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
INTRODUCTION A major goal of HIV-1 vaccine development is the design of immunogens
that induce broadly neutralizing antibodies (bnAbs). However, vaccination of humans has …
that induce broadly neutralizing antibodies (bnAbs). However, vaccination of humans has …
[HTML][HTML] Quantification of the impact of the HIV-1-glycan shield on antibody elicitation
While the HIV-1-glycan shield is known to shelter Env from the humoral immune response,
its quantitative impact on antibody elicitation has been unclear. Here, we use targeted …
its quantitative impact on antibody elicitation has been unclear. Here, we use targeted …
Structure of the hepatitis C virus E1E2 glycoprotein complex
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and
hepatocellular carcinoma in humans and afflicts more than 58 million people worldwide. The …
hepatocellular carcinoma in humans and afflicts more than 58 million people worldwide. The …
[HTML][HTML] Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
M Medina-Ramírez, F Garces, A Escolano… - Journal of Experimental …, 2017 - rupress.org
Induction of broadly neutralizing antibodies (bNAbs) by HIV-1 envelope glycoprotein
immunogens would be a major advance toward an effective vaccine. A critical step in this …
immunogens would be a major advance toward an effective vaccine. A critical step in this …
Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem
C Havenar‐Daughton, JH Lee… - Immunological reviews, 2017 - Wiley Online Library
The generation of HIV bnAbs may be one of the greatest feats of the human immune system
and our best hope of finally creating an HIV vaccine. The striking amount of somatic …
and our best hope of finally creating an HIV vaccine. The striking amount of somatic …
[HTML][HTML] Intermediate conformations of CD4-bound HIV-1 Env heterotrimers
Abstract HIV-1 envelope (Env) exhibits distinct conformational changes in response to host
receptor (CD4) engagement. Env, a trimer of gp120 and gp41 heterodimers, has been …
receptor (CD4) engagement. Env, a trimer of gp120 and gp41 heterodimers, has been …
[HTML][HTML] Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization
The production of native-like recombinant versions of the HIV-1 envelope glycoprotein (Env)
trimer requires overcoming the natural flexibility and instability of the complex. The …
trimer requires overcoming the natural flexibility and instability of the complex. The …
[HTML][HTML] Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding
Elicitation of broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal. Native-
like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are …
like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are …
[HTML][HTML] Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …