[HTML][HTML] Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus
M Zgarbová, T Otava, J Silhan, R Nencka, J Weber… - Antiviral Research, 2023 - Elsevier
Abstract The RNA 2′-O methyltransferase (MTase) VP39 of the monkeypox virus (MpxV)
participates in RNA capping within poxviruses. Sub-micromolar inhibitors targeting this …
participates in RNA capping within poxviruses. Sub-micromolar inhibitors targeting this …
Synthesis of Bisubstrate Analogues for RNA Methylation Studies using two Transition‐Metal‐Catalyzed Reactions
D Coelho, L Le Corre, K Bartosik… - … A European Journal, 2023 - Wiley Online Library
RNA methyltransferases (RNA MTases) are a family of enzymes that catalyze the
methylation of RNA using the cofactor S‐adenosyl‐L‐methionine. While RNA MTases are …
methylation of RNA using the cofactor S‐adenosyl‐L‐methionine. While RNA MTases are …
How Much Potential Do Nucleoside Analogs Offer to Combat Human Corona Viruses?
W Buchowicz, M Koszytkowska-Stawińska - Organics, 2024 - mdpi.com
Nucleoside analogs (NAs) have been extensively examined as plausible antiviral agents in
recent years, in particular since the outbreak of the global pandemic of COVID-19 in 2019. In …
recent years, in particular since the outbreak of the global pandemic of COVID-19 in 2019. In …
N-Arylsulfonamide-based adenosine analogues to target RNA cap N 7-methyltransferase nsp14 of SARS-CoV-2
R Ahmed-Belkacem, J Troussier, A Delpal… - RSC Medicinal …, 2024 - pubs.rsc.org
RNA cap methylations have been shown to be crucial for the life cycle, replication, and
infection of ssRNA viruses, as well as for evading the host's innate immune system. Viral …
infection of ssRNA viruses, as well as for evading the host's innate immune system. Viral …