Malaria vaccines: a new era of prevention and control
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …
Vaccines and monoclonal antibodies: new tools for malaria control
K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …
[HTML][HTML] Identification of RTS, S/AS01 vaccine–induced humoral biomarkers predictive of protection against controlled human malaria infection
BACKGROUND The mechanism (s) responsible for the efficacy of WHO-recommended
malaria vaccine RTS, S/AS01 are not completely understood. We previously identified RTS …
malaria vaccine RTS, S/AS01 are not completely understood. We previously identified RTS …
Monoclonal antibodies to the circumsporozoite proteins as an emerging tool for malaria prevention
Despite various public health strategies, malaria caused by Plasmodium falciparum
parasites remains a major global health challenge that requires development of new …
parasites remains a major global health challenge that requires development of new …
[HTML][HTML] TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms
Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer
Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of …
Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of …
Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals manufactured by
well‐established processes using Chinese Hamster Ovary (CHO) cells. Next‐generation …
well‐established processes using Chinese Hamster Ovary (CHO) cells. Next‐generation …
Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies
R Murugan, A Hanke, OE Oludada, G Costa… - bioRxiv, 2024 - biorxiv.org
The protective capacity of antibodies targeting circumsporozoite protein on sporozoites of
the malaria parasite Plasmodium falciparum (PfCSP) is linked to high affinity and cross …
the malaria parasite Plasmodium falciparum (PfCSP) is linked to high affinity and cross …
Survey of Chemical Unfolding Complexity as a Unique Stability Assessment Assay for Monoclonal Antibodies
JA Floyd, JM Shaver - bioRxiv, 2024 - biorxiv.org
Seventy-two intentionally sequence-diverse antibody variable regions were selected,
expressed as IgG1 antibodies, and evaluated by chemical unfolding to survey the …
expressed as IgG1 antibodies, and evaluated by chemical unfolding to survey the …
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is the most advanced
blood-stage malaria vaccine candidate and is being evaluated for efficacy in endemic …
blood-stage malaria vaccine candidate and is being evaluated for efficacy in endemic …
Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii
Y Yang - 2024 - dspace.mit.edu
Biopharmaceutical products constitute a significant portion of the global bioeconomy.
Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins …
Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins …