Antileishmanial drug discovery and development: time to reset the model?
AI Olias-Molero, C de la Fuente, M Cuquerella… - Microorganisms, 2021 - mdpi.com
Leishmaniasis is a vector-borne parasitic disease caused by Leishmania species. The
disease affects humans and animals, particularly dogs, provoking cutaneous …
disease affects humans and animals, particularly dogs, provoking cutaneous …
Quinolone: a versatile therapeutic compound class
The discovery of nalidixic acid is one pinnacle in medicinal chemistry, which opened a new
area of research that has led to the discovery of several life-saving antimicrobial agents …
area of research that has led to the discovery of several life-saving antimicrobial agents …
Recent advances in chemotherapeutics for leishmaniasis: Importance of the cellular biochemistry of the parasite and its molecular interaction with the host
Leishmaniasis, a category 1 neglected protozoan disease caused by a kinetoplastid
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …
[HTML][HTML] Sesquiterpenoids and flavonoids from Inula viscosa induce programmed cell death in kinetoplastids
Neglected tropical diseases such as leishmaniasis and American trypanosomiasis represent
an increasing health problem. Current treatments are not satisfactory which remains an …
an increasing health problem. Current treatments are not satisfactory which remains an …
Development of chimeric protein as a multivalent vaccine for human Kinetoplastid infections: Chagas disease and leishmaniasis
M de Carvalho Clímaco, LA de Figueiredo, RC Lucas… - Vaccine, 2023 - Elsevier
Leishmania spp. and Trypanosoma cruzi are parasitic kinetoplastids of great medical and
epidemiological importance since they are responsible for thousands of deaths and …
epidemiological importance since they are responsible for thousands of deaths and …
[HTML][HTML] Multi-target withaferin-A analogues as promising anti-kinetoplastid agents through the programmed cell death
D San Nicolás-Hernández… - Biomedicine & …, 2023 - Elsevier
Leishmaniasis and Chagas disease, two of the most prevalent neglected tropical diseases,
are a world health problem. The harsh reality of these infective diseases is the absence of …
are a world health problem. The harsh reality of these infective diseases is the absence of …
[HTML][HTML] Withaferin A-silyl ether analogs as potential anti-kinetoplastid agents targeting the programmed cell death
D San Nicolás-Hernández… - Biomedicine & …, 2023 - Elsevier
Current therapies of leishmaniasis and Chagas disease, two of the most widespread
neglected tropical diseases, have limited efficacy and toxic side effects. In this regard …
neglected tropical diseases, have limited efficacy and toxic side effects. In this regard …
Funding for chagas disease: A 10-year (2009–2018) survey
LS Sangenito, MH Branquinha, ALS Santos - Tropical Medicine and …, 2020 - mdpi.com
Chagas disease was discovered in 1909 by the Brazilian scientist Carlos Chagas. After
more than 110 years, many outcomes have been achieved in all research fields; however …
more than 110 years, many outcomes have been achieved in all research fields; however …
[HTML][HTML] COVID-19 pandemic causes increased clinic visits with diagnosis of tegumentary leishmaniasis in Brazil in 2020
Abstract Coronavirus disease 2019 (COVID-19) protocols has reduced primary and
secondary health care for other diseases, such as leishmaniasis, a parasitic, endemic …
secondary health care for other diseases, such as leishmaniasis, a parasitic, endemic …
Mapping the morbidity and mortality of Chagas disease in an endemic area in Brazil
CA Medeiros, MBA Silva, ALS Oliveira… - Revista do Instituto de …, 2022 - SciELO Brasil
Chagas disease is among the 21 neglected diseases according to the World Health
Organization. This study aimed to investigate the morbidity and mortality distribution of …
Organization. This study aimed to investigate the morbidity and mortality distribution of …