[HTML][HTML] IUPHAR review–Data-driven computational drug repurposing approaches for opioid use disorder
Abstract Opioid Use Disorder (OUD) is a chronic and relapsing condition characterized by
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …
Mendelian randomization and transcriptome analysis identified immune-related biomarkers for osteoarthritis
WW Pang, YS Cai, C Cao, FR Zhang, Q Zeng… - Frontiers in …, 2024 - frontiersin.org
Background The immune microenvironment assumes a significant role in the pathogenesis
of osteoarthritis (OA). However, the current biomarkers for the diagnosis and treatment of OA …
of osteoarthritis (OA). However, the current biomarkers for the diagnosis and treatment of OA …
[HTML][HTML] Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study
Introduction Psychiatric disorders present a substantial global public health burden with
limited drug options. The gut-brain axis connects inflammatory bowel diseases and …
limited drug options. The gut-brain axis connects inflammatory bowel diseases and …
Investigating the association between genetically proxied circulating levels of immune checkpoint proteins and cancer survival: protocol for a Mendelian …
T Bate, RM Martin, J Yarmolinsky, PC Haycock - BMJ open, 2024 - bmjopen.bmj.com
Introduction Compared with the traditional drug development pathway, investigating
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …
Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk
Both early childhood traumatic experiences and current stress increase the risk of suicidal
behaviour, in which immune activation might play a role. Previous research suggests an …
behaviour, in which immune activation might play a role. Previous research suggests an …
[HTML][HTML] Protocol: Investigating the association between genetically proxied circulating levels of immune checkpoint proteins and cancer survival: protocol for a …
T Bate, RM Martin, J Yarmolinsky, PC Haycock - BMJ Open, 2024 - ncbi.nlm.nih.gov
Introduction Compared with the traditional drug development pathway, investigating
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …
Alcohol drinking, DNA methylation and psychiatric disorders: A multi‐omics Mendelian randomization study to investigate causal pathways
X Shi, M Li, J Yao, MD Li, Z Yang - Addiction, 2024 - Wiley Online Library
Background and aims Whether alcohol‐related DNA methylation has a causal effect on
psychiatric disorders has not been investigated. Furthermore, a comprehensive investigation …
psychiatric disorders has not been investigated. Furthermore, a comprehensive investigation …
Cerebrospinal and Brain Proteins Implicated in Neuropsychiatric and Risk Factor Traits: Evidence from Mendelian Randomization
Neuropsychiatric disorders present a global health challenge, necessitating an
understanding of their molecular mechanisms for therapeutic development. Using …
understanding of their molecular mechanisms for therapeutic development. Using …
Large-Scale Mendelian Randomization Study Reveals Circulating Blood-based Proteomic Biomarkers for Psychopathology and Cognitive Task Performance
Background: Research on peripheral (eg, blood-based) biomarkers for psychiatric illness
has typically been low-throughput in terms of both the number of subjects and the range of …
has typically been low-throughput in terms of both the number of subjects and the range of …
Integration of tissue-specific multi-omics data implicates brain targets for complex neuropsychiatric traits
Genome-wide association studies (GWAS) have uncovered genetic variants susceptible to
brain disorders. However, due to the complex pathogenesis of these diseases and …
brain disorders. However, due to the complex pathogenesis of these diseases and …