Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …

Cells sense their physical surroundings through mechanotransduction—that is, by
translating mechanical forces and deformations into biochemical signals such as changes in …

From birth onward, the lungs are exposed to the external environment and therefore harbor
a complex immunological milieu to protect this organ from damage and infection. We …

Structural and functional complexities of the mammalian lung evolved to meet a unique set
of challenges, namely, the provision of efficient delivery of inspired air to all lung units within …

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces
regulate a large array of physiological processes, and dysregulation of mechanical …

Lung epithelial cells are subjected to large cyclic forces from breathing. However, their
response to dynamic stresses is poorly defined. We measured the complex shear modulus …

Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome
(ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema …

Mechanical ventilation is indispensable in support of patients with respiratory failure who are
critically ill. However, use of this technique has adverse effects, including increased risk of …