The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
AA Johnson, A Stolzing - Aging cell, 2019 - Wiley Online Library
An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
Associations of age, sex, race/ethnicity, and education with 13 epigenetic clocks in a nationally representative US sample: the Health and Retirement Study
Background Many DNA methylation-based indicators have been developed as summary
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort
ML Elliott, DW Belsky, AR Knodt, D Ireland… - Molecular …, 2021 - nature.com
An individual's brainAGE is the difference between chronological age and age predicted
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …
Epigenetic changes during aging and their reprogramming potential
AE Kane, DA Sinclair - Critical reviews in biochemistry and …, 2019 - Taylor & Francis
The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …
The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …
there is considerable between-person variation in the rate of ageing and individual …
[HTML][HTML] DNA methylation-based estimator of telomere length
Telomere length (TL) is associated with several aging-related diseases. Here, we present a
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …
[HTML][HTML] What is new in the exposome?
P Vineis, O Robinson, M Chadeau-Hyam… - Environment …, 2020 - Elsevier
The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …
internal sources including chemical agents, biological agents, or radiation, from conception …
[HTML][HTML] 60 years of healthy aging: on definitions, biomarkers, scores and challenges
LC Behr, A Simm, A Kluttig, A Grosskopf - Ageing Research Reviews, 2023 - Elsevier
ABSTRACT BACKGROUND AND OBJECTIVE As the proportion of aging people in our
population increases steadily, global strategies accompanied by extensive research are …
population increases steadily, global strategies accompanied by extensive research are …
[HTML][HTML] DNA methylation GrimAge version 2
We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
[HTML][HTML] Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities
The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …