Transcription by RNA polymerase II (Pol II) in metazoans is regulated in several steps,
including preinitiation complex (PIC) formation, initiation, Pol II escape, productive …

Influenza virus intimately associates with host RNA polymerase II (Pol II) and mRNA
processing machinery. Here, we use mammalian native elongating transcript sequencing …

The human nuclear poly (A)-binding protein PABPN1 has been implicated in the decay of
nuclear noncoding RNAs (ncRNAs). In addition, PABPN1 promotes hyperadenylation by …

Although it is established that some general transcription factors are inactivated at mitosis,
many details of mitotic transcription inhibition (MTI) and its underlying mechanisms are …

Eukaryotic genes are marked by conserved post-translational modifications on the RNA pol
II C-terminal domain (CTD) and the chromatin template. How the 5′-3′ profiles of these …

Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies,
including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant …

Many viruses block host gene expression to take over the infected cell. This process, termed
host shutoff, is thought to promote viral replication by preventing antiviral responses and …

The regulation of mRNA degradation is critical for proper gene expression. Many major
pathways for mRNA decay involve the removal of the 5′ 7-methyl guanosine (m7G) cap in …

Spt5 is an essential and conserved factor that functions in transcription and co-
transcriptional processes. However, many aspects of the requirement for Spt5 in …

Regulation of gene expression is critical in determining cell identity, development, and
responses to the cellular environment. DNA is the inherited source of genetic information …