[HTML][HTML] Potential therapeutic effects of ppar ligands in glioblastoma

R Basilotta, M Lanza, G Casili, G Chisari, S Munao… - Cells, 2022 - mdpi.com
Glioblastoma (GB), also known as grade IV astrocytoma, represents the most aggressive
form of brain tumor, characterized by extraordinary heterogeneity and high invasiveness and …

[HTML][HTML] Sodium propionate contributes to tumor cell growth inhibition through PPAR-γ signaling

A Filippone, G Casili, SA Scuderi, D Mannino, M Lanza… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most aggressive primary brain tumor with no
positive outcome. Interesting pieces of evidence indicate the short-chain fatty acids (SFCAs) …

[HTML][HTML] The PPARβ/δ-AMPK connection in the treatment of insulin resistance

D Aguilar-Recarte, X Palomer, W Wahli… - International Journal of …, 2021 - mdpi.com
The current treatment options for type 2 diabetes mellitus do not adequately control the
disease in many patients. Consequently, there is a need for new drugs to prevent and treat …

Addressing genetic tumor heterogeneity, post-therapy metastatic spread, cancer repopulation, and development of acquired tumor cell resistance

DC Harrer, F Lüke, T Pukrop, L Ghibelli, A Reichle… - Cancers, 2023 - mdpi.com
Simple Summary The present review summarizes and interprets uniform therapy schemes
for rescuing relapsed or refractory (r/r) neoplasias of quite different histologic origins …

[HTML][HTML] Multi-faceted role of cancer-associated adipocytes in colorectal cancer

A Grigoraș, C Amalinei - Biomedicines, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the most commonly diagnosed types of cancer, especially
in obese patients, and the second cause of cancer-related death worldwide. Based on these …

Gene set correlation enrichment analysis for interpreting and annotating gene expression profiles

LY Chang, MZ Lee, Y Wu, WK Lee, CL Ma… - Nucleic acids …, 2024 - academic.oup.com
Pathway analysis, including nontopology-based (non-TB) and topology-based (TB)
methods, is widely used to interpret the biological phenomena underlying differences in …

Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis

Y Miao, X Wu, X Xue, X Ma, L Yang, X Zeng… - Cell Biology and …, 2023 - Springer
T helper (Th) 17 cells highly contribute to the immunopathology of rheumatoid arthritis.
Morin, a natural flavonoid, owns well anti-arthritic action but unclear effect on Th17 …

[HTML][HTML] Phenylsulfonimide PPARα Antagonists enhance nrf2 activation and promote oxidative stress-induced apoptosis/pyroptosis in MCF7 breast cancer cells

M Gallorini, V Di Valerio, I Bruno, S Carradori… - International Journal of …, 2023 - mdpi.com
The NF-E2-related factor 2 transcription factor (Nrf2) orchestrates the basal and stress-
inducible activation of a vast array of antioxidant genes. A high amount of reactive oxygen …

[HTML][HTML] Exploring the nexus of nuclear receptors in hematological malignancies

MK Manickasamy, A Sajeev… - Cellular and Molecular …, 2024 - Springer
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood,
bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and …

The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics

G Dixit, A Prabhu - Experimental and Molecular Pathology, 2022 - Elsevier
The Peroxisome proliferator-activated receptors (PPARs) are key regulators of metabolic
events in our body. Owing to their implication in maintenance of homeostasis, both PPAR …