The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …

The therapeutic potential of Cannabis sativa has been recognized since ancient times.
Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two major G …

Drug resistance is a serious challenge for platinum anticancer drugs. Platinum complexes
may get over the drug resistance via a distinct mechanism of action. Cholesterol is a key …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) has emerged as one of the most
extensively studied transcription factors since its discovery in 1990, highlighting its …

Hepatocellular carcinoma (HCC), the main pathological type of liver cancer, is linked to risk
factors such as viral hepatitis, alcohol intake and non‐alcoholic fatty liver disease (NAFLD) …

Cancers are a frequent cause of morbidity and mortality. There are many risk factors for
tumours, including advanced age, personal or family history of cancer, some types of viral …

Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …

Despite some significant advancements, breast cancer has become the most prevalent
cancer in the world. One of the main reasons for failure in treatment and metastasis has …

Peroxisome proliferator‐activated receptors (PPARs) are transcription factors belonging to
the nuclear receptor family. There are three subtypes of PPARs, including PPAR‐α, PPAR …

Cancer stem cells (CSCs) have been demonstrated to be involved in tumor initiation and
relapse, and the presence of CSCs in the tumor tissue often leads to therapeutic failure …