Psychiatric stress has been associated with accelerated epigenetic aging (ie, when
estimates of cellular age based on DNA methylation exceed chronological age) in both …

Background Increasing life expectancy but also healthspan seems inaccessible as of yet but
it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil …

The link between childhood adversity and adulthood depression is well-established;
however, the underlying mechanisms are still being explored. Recent research suggests …

Background Hazardous alcohol consumption has significant adverse medical
consequences. These effects may be mediated, in part, by alterations in DNA methylation …

We define and discuss several proposed biological aging markers that have been examined
in SMDs, we review the most recent findings, and we conclude with opinions regarding the …

The genome (genes), epigenome, and environment work together from the earliest stages of
human life to produce a phenotype of human health or disease. Epigenetic modifications …

Background Autism spectrum disorder (ASD) is characterized by impaired social
communication and behavioral problems. An increased risk of premature mortality has been …

Selective serotonin reuptake inhibitors (SSRIs) for treatment of prenatal maternal depression
have been associated with neonatal neurobehavioral disturbances, though the molecular …

Background Psychiatric disorders have been associated with advanced epigenetic age in
DNA methylation, yet this relationship has not been studied in the brain transcriptome. We …

Gerontological research reveals considerable interindividual variability in aging phenotypes,
which has motivated research efforts to identify “aging biomarkers.” Aging biomarkers are …