Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

Abstract Theory predicts that biological processes of aging may contribute to poor mental
health in late life. To test this hypothesis, we evaluated prospective associations between …

Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …

Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Background: Childhood trauma (CT) has adverse consequences on mental health across
the lifespan. The understanding of how CT increases vulnerability for psychiatric disorders is …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …

Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …