The future of brain circuit-targeted therapeutics

SH Siddiqi, S Khosravani, JD Rolston… - …, 2024 - nature.com
The principle of targeting brain circuits has drawn increasing attention with the growth of
brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain …

[HTML][HTML] Functional dysconnectivity in youth depression: Systematic review, meta‐analysis, and network-based integration

NY Tse, A Ratheesh, S Ganesan, A Zalesky… - Neuroscience & …, 2023 - Elsevier
Youth depression has been associated with heterogenous patterns of aberrant brain
connectivity. To make sense of these divergent findings, we conducted a systematic review …

Non-invasively targeting, probing and modulating a deep brain circuit for depression alleviation

DJ Oathes, RJP Duprat, J Reber, X Liang… - Nature Mental …, 2023 - nature.com
Effective repetitive transcranial magnetic stimulation (rTMS) treatment for depression has
often focused on modulating the subgenual anterior cingulate cortex (sgACC), but no …

[HTML][HTML] Evaluating robustness of brain stimulation biomarkers for depression: a systematic review of MRI and EEG studies

D Klooster, H Voetterl, C Baeken, M Arns - Biological psychiatry, 2023 - Elsevier
Non-invasive brain stimulation (NIBS) treatments have gained considerable attention as a
potential therapeutic intervention for psychiatric disorders. The identification of reliable …

Elevating the field for applying neuroimaging to individual patients in psychiatry

DR Roalf, M Figee, DJ Oathes - Translational Psychiatry, 2024 - nature.com
Although neuroimaging has been widely applied in psychiatry, much of the exuberance in
decades past has been tempered by failed replications and a lack of definitive evidence to …

[HTML][HTML] Personalized and circuit-based transcranial magnetic stimulation: Evidence, controversies, and opportunities

RFH Cash, A Zalesky - Biological Psychiatry, 2024 - Elsevier
The development of neuroimaging methodologies to map brain connectivity has transformed
our understanding of psychiatric disorders, the distributed effects of brain stimulation, and …

Divergent suicidal symptomatic activations converge on somato-cognitive action network in depression

J Li, D Wang, J Xia, C Zhang, Y Meng, S Xu… - Molecular …, 2024 - nature.com
Individuals with depression have the highest lifetime prevalence of suicide attempts (SA)
among mental illnesses. Numerous neuroimaging studies have developed biomarkers from …

[HTML][HTML] Predicting Treatment Outcome Based on Resting-State Functional Connectivity in Internalizing Mental Disorders: A Systematic Review and Meta-Analysis

C Meinke, U Lueken, H Walter, K Hilbert - Neuroscience & Biobehavioral …, 2024 - Elsevier
Predicting treatment outcome in internalizing mental disorders prior to treatment initiation is
pivotal for precision mental healthcare. In this regard, resting-state functional connectivity (rs …

Connectomics reconciles seemingly irreconcilable neuroimaging findings

M Xia, Y He - Trends in Cognitive Sciences, 2023 - cell.com
Neuroimaging studies have reported heterogeneity of regional anatomical localization for
the same disease, impeding reproducible conclusions regarding brain alterations. In recent …

Additive effects of depression and obesity on neural correlates of inhibitory control

LK Kaufmann, E Custers, D Vreeken, J Snabel… - Journal of Affective …, 2024 - Elsevier
Background Depression and obesity are associated with impaired inhibitory control.
Behavioral evidence indicates an exacerbating additive effect when both conditions co …