Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

CMC Andrés, JM Pérez de la Lastra… - International Journal of …, 2024 - mdpi.com
The phrase “Let food be thy medicine…” means that food can be a form of medicine and
medicine can be a form of food; in other words, that the diet we eat can have a significant …

The promise of explainable ai in digital health for precision medicine: a systematic review

B Allen - Journal of Personalized Medicine, 2024 - mdpi.com
This review synthesizes the literature on explaining machine-learning models for digital
health data in precision medicine. As healthcare increasingly tailors treatments to individual …

Integrating pharmacogenomic testing into personalized medicine practices in the USA: Implications for medication quality control and therapeutic efficacy

JT Bature, MA Eruaga, EO Itua - GSC Biological and …, 2024 - gsconlinepress.com
This concept paper explores the integration of pharmacogenomic testing into personalized
medicine practices in the USA and its implications for medication quality control and …

COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers

P Rodrigues, H Bangali, A Hammoud, YF Mustafa… - Medical Oncology, 2024 - Springer
Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …

Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy

S Xu, Q Wang, W Ma - Cytokine & Growth Factor Reviews, 2024 - Elsevier
Navigating the intricate landscape of the tumor microenvironment (TME) unveils a pivotal
arena for cancer therapeutics, where cytokines and soluble mediators emerge as double …

[HTML][HTML] A hybrid machine learning model for classifying gene mutations in cancer using LSTM, BiLSTM, CNN, GRU, and GloVe

S Aburass, O Dorgham, J Al Shaqsi - Systems and Soft Computing, 2024 - Elsevier
In our study, we introduce a novel hybrid ensemble model that synergistically combines
LSTM, BiLSTM, CNN, GRU, and GloVe embeddings for the classification of gene mutations …

Machine Learning in Drug Discovery: A critical review of applications and challenges

FC Udegbe, OR Ebulue, CC Ebulue… - Computer Science & IT …, 2024 - fepbl.com
This review critically examines the integration of Machine Learning (ML) in drug discovery,
highlighting its applications across target identification, hit discovery, lead optimization, and …

[PDF][PDF] Transforming toxicity assessment through microphysiology, bioprinting, and computational modeling

TA Addissouky, Y Wang… - Advances in Clinical …, 2024 - researchgate.net
Background: Traditional toxicity testing emphasizes animal models with growing concerns
regarding predictive capacity, throughput and ethics. Rapid innovation surrounding human …

Precision Medicine and Genomics: A comprehensive review of IT-enabled approaches

FC Udegbe, OR Ebulue, CC Ebulue… - International Medical …, 2024 - fepbl.com
This review delves into Information Technology's (IT) transformative impact on precision
medicine and genomics, spotlighting the pivotal role of bioinformatics, data mining, machine …

Recent advancements in nanoconstructs for the theranostics applications for triple negative breast cancer

A Gupta, K Nishchaya, M Saha, GARR Naik… - Journal of Drug Delivery …, 2024 - Elsevier
Cancer is a major public health concern worldwide; it is the second-highest cause of death
in the United States. According to projections of cancer incidence and mortality rates …