The heterocellular heart: identities, interactions, and implications for cardiology

A Lother, P Kohl - Basic Research in Cardiology, 2023 - Springer
The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

[HTML][HTML] Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies

S Ravassa, B López, TA Treibel, G San José… - Molecular Aspects of …, 2023 - Elsevier
Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Modelling the pathology and treatment of cardiac fibrosis in vascularised atrial and ventricular cardiac microtissues

JS Reyat, A di Maio, B Grygielska, J Pike… - Frontiers in …, 2023 - frontiersin.org
Introduction Recent advances in human cardiac 3D approaches have yielded progressively
more complex and physiologically relevant culture systems. However, their application in the …

A Biomimetic Cardiac Fibrosis-on-a-Chip as a Visible Disease Model for Evaluating Mesenchymal Stem Cell-Derived Exosome Therapy

Y Shang, L Sun, J Gan, D Xu, Y Zhao, L Sun - ACS nano, 2023 - ACS Publications
Cardiac fibrosis acts as a serious worldwide health issue due to its prevalence in numerous
forms of cardiac disease and its essential link to cardiac failure. Considering the efficiency of …

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

R Chen, H Zhang, B Tang, Y Luo, Y Yang… - … and Targeted Therapy, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

Anisotropically Deforming Sandwich-Type Self-Oscillating Gels: A Hierarchical Model Platform of Cardiac Tissue

WS Lee, T Enomoto, A Mizutani Akimoto… - Chemistry of …, 2024 - ACS Publications
Here, we present sandwich-type self-oscillating gels as a potential model for exploring the
cardiac hierarchy and derived emergent properties. The sandwich-type self-oscillating gels …

Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: The paradigm of radiotherapy

S Logotheti, A Pavlopoulou, HK Rudsari… - Pharmacology & …, 2024 - Elsevier
Advances in cancer therapeutics have improved patient survival rates. However, cancer
survivors may suffer from adverse events either at the time of therapy or later in life …

Cardiovascular Organoids/3D Models Review Series: An Introduction

C St. Hilaire - Circulation research, 2023 - Am Heart Assoc
Even with the vast amount of research focused on uncovering the etiology and molecular
mechanisms that drive the progression of cardiovascular disease, along with concerted …

Advances in the Generation of Constructed Cardiac Tissue Derived from Induced Pluripotent Stem Cells for Disease Modeling and Therapeutic Discovery

TJ Roland, K Song - Cells, 2024 - mdpi.com
The human heart lacks significant regenerative capacity; thus, the solution to heart failure
(HF) remains organ donation, requiring surgery and immunosuppression. The demand for …

NAVIGATING THE VASCULAR FRONTIER: EXPLORING QUERCETIN-BASED DRUG DELIVERY STRATEGIES IN CARDIOVASCULAR THERAPY

HMU Abid, M Azeem, M Qaiser, MT Faqeer… - Journal of Population …, 2024 - jptcp.com
This comprehensive review delves into the utilization of quercetin-based drug delivery
systems in cardiovascular therapy, with a primary focus on various nanoparticle strategies …