Recent Advances in Molecular Mechanisms of Nucleoside Antivirals
PN Kamzeeva, AV Aralov, VA Alferova… - Current Issues in …, 2023 - mdpi.com
The search for new drugs has been greatly accelerated by the emergence of new viruses
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …
The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome
T Krischuns, B Arragain, C Isel, S Paisant… - Nature …, 2024 - nature.com
The current model is that the influenza virus polymerase (FluPol) binds either to host RNA
polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its …
polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its …
Exploring nucleoside analogs: key targets in the viral life cycle-advancing strategies against SARS-CoV-2
R Garg, R Kumar, R Srivastava… - Medicinal Chemistry …, 2024 - Springer
The COVID-19 pandemic has been a major reason behind the increased research aimed at
the identification of effective antiviral agents. Among these, Nucleoside analogs have shown …
the identification of effective antiviral agents. Among these, Nucleoside analogs have shown …
Regulation of viral RNA-dependent RNA polymerases by phosphorylation
C Duflos, T Michiels - Frontiers in Virology, 2023 - frontiersin.org
RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which is essential for
transcription and replication of their genome since host cells lack equivalent enzymes. RdRp …
transcription and replication of their genome since host cells lack equivalent enzymes. RdRp …
T-705-Derived Prodrugs Show High Antiviral Efficacies against a Broad Range of Influenza A Viruses with Synergistic Effects When Combined with Oseltamivir
B Ganter, M Zickler, J Huchting, M Winkler… - Pharmaceutics, 2023 - mdpi.com
Emerging influenza A viruses (IAV) bear the potential to cause pandemics with
unpredictable consequences for global human health. In particular, the WHO has declared …
unpredictable consequences for global human health. In particular, the WHO has declared …
Application of Cryoelectron Microscopy in Antiviral Research
P Narula, MK Lokshman, M Banerjee - Advances in Antiviral Research, 2024 - Springer
In the last decade, single-particle reconstruction from cryoelectron micrographs has been
established as a powerful technique for generating high-resolution structures of biological …
established as a powerful technique for generating high-resolution structures of biological …