P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

The human SLC29 family of proteins contains four members, designated equilibrative
nucleoside transporters (ENTs) because of the properties of the first-characterised family …

This review addresses three principal questions about adenosine and sleep–wake
regulation:(1) Is adenosine an endogenous sleep factor?(2) Are there specific brain regions …

The plant-derived cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD)
both have immunosuppressive effects; although some effects of THC are mediated by the …

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most chemoresistant
cancers, and current therapies targeting cancer-associated molecular pathways have not …

Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine
arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) …

BACKGROUND & AIMS: The human equilibrative nucleoside transporter (hENT1) protein
transports gemcitabine into cells. Small retrospective studies in pancreatic cancer suggest …

Purpose: Gemcitabine monotherapy is the standard palliative chemotherapy for pancreatic
adenocarcinoma. Gemcitabine requires plasma membrane nucleoside transporter proteins …