Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …

Abnormal immunological indicators associated with disease severity and mortality in
patients with COVID-19 have been reported in several observational studies. However …

Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical
outcomes ranging from asymptomatic to severe disease and death. We previously reported …

We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited
deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons …

Background The COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a global crisis. Although many people recover from COVID …

The local immune-inflammatory response elicited by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is still poorly described, as well as the extent to which …

Abstract SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense
single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper …

Vaccination has been a game changer in our efforts to address the coronavirus disease
2019 (COVID-19) pandemic. However, the disease might still represent a clinical crisis for …

Community-acquired pneumonia (CAP) is a common lower respiratory tract infection, often
complicated by cardiovascular events, including cardiac arrhythmias. New-onset atrial …

Unfractionated heparin has multiple pharmacological activities beyond anticoagulation.
These anti-inflammatory, anti-microbial, and mucoactive activities are shared in part by low …