With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

The global vaccine market is diverse while facing a plethora of novel developments. Genetic
modification (GM) techniques facilitate the design of'smarter'vaccines. For many of the major …

The leading malaria vaccine in development is the circumsporozoite protein (CSP)-based
particle vaccine, RTS, S, which targets the pre-erythrocytic stage of Plasmodium falciparum …

The development of a highly effective vaccine remains a key strategic goal to aid the control
and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte …

Protective immunity to the liver stage of the malaria parasite can be conferred by vaccine-
induced T cells, but no subunit vaccination approach based on cellular immunity has shown …

Background RH5 is a leading blood-stage candidate antigen for a Plasmodium falciparum
vaccine; however, its safety and immunogenicity in malaria-endemic populations are …

Background Transmission blocking vaccines targeting the sexual-stages of the malaria
parasite could play a major role to achieve elimination and eradication of malaria. The …

Background The West African outbreak of Ebola virus disease has caused more than 8500
deaths. A vaccine could contribute to outbreak control in the region. We assessed a …

Background. The need for a highly efficacious vaccine against Plasmodium falciparum
remains pressing. In this controlled human malaria infection (CHMI) study, we assessed the …

Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …