Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

[HTML][HTML] Cell death in the origin and treatment of cancer

A Strasser, DL Vaux - Molecular cell, 2020 - cell.com
Cell death, or, more specifically, cell suicide, is a process of fundamental importance to
human health. Throughout our lives, over a million cells are produced every second. When …

Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts

D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Death and anti-death: tumour resistance to apoptosis

FH Igney, PH Krammer - Nature Reviews Cancer, 2002 - nature.com
Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also …

Lipid droplets: A cellular organelle vital in cancer cells

Y Jin, Y Tan, J Wu, Z Ren - Cell death discovery, 2023 - nature.com
Lipid droplets (LDs) are cellular organelles comprising a core of neutral lipids (glycerides,
sterols) encased within a single phospholipid membrane, responsible for storing surplus …

Apoptosis: a link between cancer genetics and chemotherapy

RW Johnstone, AA Ruefli, SW Lowe - Cell, 2002 - cell.com
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of
these defects chemotherapy often fails. Understanding the molecular events that contribute …

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

MJ Piao, KA Kang, IK Lee, HS Kim, S Kim, JY Choi… - Toxicology letters, 2011 - Elsevier
Silver nanoparticles (AgNPs), which have well-known antimicrobial properties, are
extensively used in various medical and general applications. Despite the widespread use …

[HTML][HTML] Secondary necrosis: the natural outcome of the complete apoptotic program

MT Silva - FEBS letters, 2010 - Elsevier
The predominant definition of apoptosis considers that the elimination of the apoptosing cell
is by heterolytic degradation following phagocytosis by an assisting scavenger …

Cell death independent of caspases: a review

LE Broker, FAE Kruyt, G Giaccone - Clinical Cancer Research, 2005 - AACR
Patterns of cell death have been divided into apoptosis, which is actively executed by
specific proteases, the caspases, and accidental necrosis. However, there is now …