Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Adult-onset autoimmune (AOA) diabetes pathophysiology starts with immune changes,
followed by dysglycaemia and overt disease. AOA diabetes can occur as classic type 1 …

Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels
are promising systems for DFU-based wound management, their effectiveness is often …

In this perspective, we provide an overview of a recently established National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas …

BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1
diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only …

First envisioned by early diabetes clinicians, a person-centred approach to care was an
aspirational goal that aimed to match insulin therapy to each individual's unique …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Human pancreatic plasticity is implied from multiple single-cell RNA sequencing (scRNA-
seq) studies. However, these have been invariably based on static datasets from which fate …

Pancreatic islets consist of multiple cell types that produce hormones required for glucose
homeostasis, and islet dysfunction is a major factor in type 1 and type 2 diabetes. Numerous …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …