Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …

Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue
and not only perturb the tumour signal in molecular studies but also have an important role …

Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

Cancer stem cells (CSCs) are the main culprits involved in therapy resistance and disease
recurrence in colorectal carcinoma (CRC). Results using cell culture, animal models and …

Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

Epithelial cell adhesion molecule (EpCAM) is overexpressed in most solid cancers and is an
ideal antigen for clinical applications in cancer diagnosis, prognosis, imaging, and therapy …

Metastases are the most common cause of cancer-related death in patients with solid
tumors.[1–4] A considerable body of evidence indicates that tumor cells are shed from a …