Abstract Cyclin‐Dependent Kinase 9 (CDK9) is part of a functional diverse group of
enzymes responsible for cell cycle control and progression. It associates mainly with Cyclin …

Besides BRCA1 and BRCA2, several other inheritable mutations have been identified that
increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces …

Abstract RNF40 (OMIM: 607700) is a really interesting new gene (RING) finger E3 ubiquitin
ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which …

Simple Summary Post-translational modifications (PTM) of histone tails represent
epigenomic regulation of the chromatin landscape, influencing gene expression and the …

Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …

There is growing evidence highlighting the importance of monoubiquitination as part of the
histone code. Monoubiquitination, the covalent attachment of a single ubiquitin molecule at …

Ubiquitin-Specific Peptidase 22 (USP22) is a ubiquitin hydrolase, notably catalyzing the
removal of the mono-ubiquitin moiety from histone H2B (H2Bub1). Frequent overexpression …

Recent insights supporting the fallopian tube epithelium (FTE) and serous tubal
intraepithelial carcinomas (STIC) as the tissue of origin and the precursor lesion …

Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is implicated in the control of
multiple essential processes, including transcription, DNA damage repair and mitotic …

Evolving strategies to counter cancer initiation and progression rely on the identification of
novel therapeutic targets that exploit the aberrant genetic changes driving oncogenesis …