Harnessing microalgae as sustainable cellular factories for biopharmaceutical production

H Goshtasbi, YB Okolodkov, A Movafeghi, S Awale… - Algal research, 2023 - Elsevier
The biotechnology sector centered around microalgae is experiencing a remarkable surge
in growth. So far, over 300,000 distinct species of microalgae have been meticulously …

Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease

H Barmaki, A Nourazarian… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta
and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps …

Bibliometric analysis of research on Alzheimer's disease and non-coding RNAs: opportunities and challenges

X Fei, S Wang, J Li, Q Zeng, Y Gao… - Frontiers in Aging …, 2022 - frontiersin.org
Background Non-coding RNAs (ncRNA) are a kind of RNA that does not encode protein,
which play an important role in Alzheimer's disease (AD). However, there is a lack of …

Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications

BC Tang, YT Wang, J Ren - Ibrain, 2023 - Wiley Online Library
Memantine is a noncompetitive moderate‐affinity strong voltage‐dependent N‐methyl‐D‐
aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since …

Therapeutics of Alzheimer's disease: Recent developments

S Burns, A Selman, U Sehar, P Rawat, AP Reddy… - Antioxidants, 2022 - mdpi.com
With increasing aging, dementia is a growing public health concern globally. Patients with
dementia have multiple psychological and behavioral changes, including depression …

A comprehensive bibliometric analysis of global research on the role of acrolein in Alzheimer's disease pathogenesis: involvement of amyloid-beta

AW Jallow, DPQ Nguyen, MR Sanotra… - Frontiers in Aging …, 2024 - frontiersin.org
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by cognitive and behavioral decline. Acrolein, an environmental pollutant and …

Calcium (Ca2+) hemostasis, mitochondria, autophagy, and mitophagy contribute to Alzheimer's disease as early moderators

F Hadi, M Mortaja, Z Hadi - Cell Biochemistry and Function, 2024 - Wiley Online Library
This review rigorously investigates the early cerebral changes associated with Alzheimer's
disease, which manifest long before clinical symptoms arise. It presents evidence that the …

Toward a new nosology of neurodegenerative diseases

M Menéndez‐González - Alzheimer's & Dementia, 2023 - Wiley Online Library
New “omic” technologies are revealing shared and distinct biological pathways within and
across neurodegenerative diseases (NDDs), allowing a better understanding of …

Diversity of amyloid beta peptide actions

S Mardanyan, S Sharoyan, A Antonyan - Reviews in the …, 2024 - degruyter.com
Fibril formation by amyloidogenic proteins and peptides is considered the cause of a
number of incurable diseases. One of the most known amyloid diseases is Alzheimer's …

Design, synthesis and evaluation of benzo [cd] indol-2 (1H)-one-donepezil hybrids as cholinesterase inhibitors and living cell imaging agents

J Wang, H Zhou, Y Li, Y Mu, J Li, C Hong… - Journal of Molecular …, 2023 - Elsevier
A novel series of benzo [cd] indol-2 (1H)-one-donepezil (BIO-DPZ) hybrids (5a-m, 6a-k) was
designed, synthesized and evaluated as cholinesterase inhibitors and living cell imaging …