[HTML][HTML] Physiology of hyperuricemia and urate-lowering treatments
CL Benn, P Dua, R Gurrell, P Loudon, A Pike… - Frontiers in …, 2018 - frontiersin.org
Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …
typically characterized by hyperuricemia and monosodium urate crystal deposition …
An update on the genetics of hyperuricaemia and gout
A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …
the formation of monosodium urate crystals. The clinical features of gout result from an …
Associations between blood type and COVID-19 infection, intubation, and death
The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …
testing resources, making the identification and prioritization of individuals most at-risk a …
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases
Clinical measurements can be viewed as useful intermediate phenotypes to promote
understanding of complex human diseases. To acquire comprehensive insights into the …
understanding of complex human diseases. To acquire comprehensive insights into the …
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
Large-scale whole-genome sequencing studies have enabled the analysis of rare variants
(RVs) associated with complex phenotypes. Commonly used RV association tests have …
(RVs) associated with complex phenotypes. Commonly used RV association tests have …
New genetic loci link adipose and insulin biology to body fat distribution
D Shungin, TW Winkler, DC Croteau-Chonka… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta …
Background Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and
assess glycemic control in patients with diabetes. Previous genome-wide association …
assess glycemic control in patients with diabetes. Previous genome-wide association …
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …
Mapping and analysis of chromatin state dynamics in nine human cell types
Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …
of regulatory activity. The approach is especially well suited to the characterization of non …
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct
alternative non–foam cell antiinflammatory macrophage phenotype that was previously …
alternative non–foam cell antiinflammatory macrophage phenotype that was previously …