[HTML][HTML] Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …
[HTML][HTML] The role of galectins in immunity and infection
FT Liu, SR Stowell - Nature Reviews Immunology, 2023 - nature.com
The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by
a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in …
a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in …
Glycosylation in SARS-CoV-2 variants: A path to infection and recovery
Glycan is an essential molecule that controls and drives life in a precise direction. The
paucity of research in glycobiology may impede the significance of its role in the pandemic …
paucity of research in glycobiology may impede the significance of its role in the pandemic …
SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
The main protease of SARS-CoV-2 (Mpro) is the most promising drug target against
coronaviruses due to its essential role in virus replication. With newly emerging variants …
coronaviruses due to its essential role in virus replication. With newly emerging variants …
[HTML][HTML] Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome
Introduction A group of SARS-CoV-2 infected individuals present lingering symptoms,
defined as long COVID (LC), that may last months or years post the onset of acute disease …
defined as long COVID (LC), that may last months or years post the onset of acute disease …
The quality of SARS-CoV-2–specific T cell functions differs in patients with mild/moderate versus severe disease, and T cells expressing coinhibitory receptors are …
Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for the monitoring of
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
[HTML][HTML] Characterization by quantitative serum proteomics of immune-related prognostic biomarkers for COVID-19 symptomatology
The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors
affecting disease progression and severity. The identification of prognostic biomarkers and …
affecting disease progression and severity. The identification of prognostic biomarkers and …
Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles
There is an urgent need to better understand the impact of different severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
[HTML][HTML] Galectin-9 promotes natural killer cells activity via interaction with CD44
Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules.
Their effector functions are tightly synchronized by the balance between the stimulatory and …
Their effector functions are tightly synchronized by the balance between the stimulatory and …
[HTML][HTML] Depletion of polyfunctional CD26highCD8+ T cells repertoire in chronic lymphocytic leukemia
N Bozorgmehr, M Hnatiuk, AC Peters… - … Hematology & Oncology, 2023 - Springer
Background CD8+ T cells play an essential role against tumors but the role of human CD8+
CD26+ T cell subset against tumors, in particular, haematological cancers such as chronic …
CD26+ T cell subset against tumors, in particular, haematological cancers such as chronic …