Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …

MicroRNAs (miRNAs) are short (18–25 nt), non-coding, widely conserved RNA molecules
responsible for regulating gene expression via sequence-specific post-transcriptional …

High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …

Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important
second messengers in signal transduction. However, when the accumulation of these …

Inflammation represents the first-line defense mechanism of the host against pathogens and
cellular stress. One of the most critical inflammatory responses is characterized by the …

The discovery of therapeutic miRNAs is one of the most exciting challenges for
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …

Aims Inflammation of the heart is a complex biological and pathophysiological response of
the immune system to a variety of injuries leading to tissue damage and heart failure …

Despite significant progress in medicine, pancreatic cancer is one of the most tardily
diagnosed cancer and is consequently associated with a poor prognosis and a low survival …

New evidence has suggested that non-coding microRNAs play a significant role in
mediating and modulating chemotherapy resistance, particularly among oral cancers. One …

Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-
145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral …