Neuromodulation in epilepsy: state-of-the-art approved therapies

P Ryvlin, S Rheims, LJ Hirsch, A Sokolov… - The Lancet …, 2021 - thelancet.com
Three neuromodulation therapies have been appropriately tested and approved in refractory
focal epilepsies: vagus nerve stimulation (VNS), deep brain stimulation of the anterior …

Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions

Y Shan, H Wang, Y Yang, J Wang, W Zhao… - Molecular …, 2023 - nature.com
Deep brain regions such as hippocampus, insula, and amygdala are involved in
neuropsychiatric disorders, including chronic insomnia and depression. Our recent reports …

The SANTÉ study at 10 years of follow‐up: effectiveness, safety, and sudden unexpected death in epilepsy

V Salanova, MR Sperling, RE Gross, CP Irwin… - …, 2021 - Wiley Online Library
Objective We evaluated the efficacy and safety of deep brain anterior thalamus stimulation
after 7 and 10 years, and report the incidence of sudden unexpected death in epilepsy …

Fast-specific fluorescent probes to visualize norepinephrine signaling pathways and its flux in the epileptic mice brain

H Yan, Y Wang, F Huo, C Yin - Journal of the American Chemical …, 2023 - ACS Publications
Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout
the brain and spinal cord. It regulates various actions and consciousness linked to a variety …

Deep brain stimulation targets in epilepsy: systematic review and meta‐analysis of anterior and centromedian thalamic nuclei and hippocampus

A Vetkas, A Fomenko, J Germann, C Sarica… - …, 2022 - Wiley Online Library
Deep brain stimulation (DBS) is a neuromodulatory treatment used in patients with drug‐
resistant epilepsy (DRE). The primary goal of this systematic review and meta‐analysis is to …

Epilepsy in China: major progress in the past two decades

D Ding, D Zhou, JW Sander, W Wang, S Li… - The Lancet …, 2021 - thelancet.com
China has approximately 10 million people with epilepsy. There is a vast epilepsy treatment
gap in China, mainly driven by deficiencies in health-care delivery and social discrimination …

Emerging technologies for improved deep brain stimulation

H Cagnan, T Denison, C McIntyre, P Brown - Nature biotechnology, 2019 - nature.com
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …

Practical considerations in epilepsy neurostimulation

HD Simpson, A Schulze‐Bonhage, GD Cascino… - …, 2022 - Wiley Online Library
Neuromodulation is a key therapeutic tool for clinicians managing patients with drug‐
resistant epilepsy. Multiple devices are available with long‐term follow‐up and real‐world …

Discrete subicular circuits control generalization of hippocampal seizures

F Fei, X Wang, C Xu, J Shi, Y Gong, H Cheng… - Nature …, 2022 - nature.com
Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …