The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

Abstract The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …

Acute kidney injury (AKI) is a common clinical problem and an efficacious treatment is
lacking. Ferroptosis, a newly discovered type of programmed cell death, has been reported …

Abstract COMT (catechol-O-methyltransferase) inhibitors are key therapeutic agents in the
management of motor fluctuations (MF) in patients with Parkinson's disease (PD). As …

We report an organocatalytic trans hydroboration of 3-substituted-propiolonitriles. In the
presence of catalytic amounts of tributylphosphine and pinacolborane, regioselective …

methoxyestradiol (2-ME), an estrogen metabolite generated via catechol-o-
methyltransferase (COMT), is multifunctional methoxy-catechol. Here, we report that COMT …

Entacapone, a reversible catechol-o-methyl transferase inhibitor, is used to enhance the
action of dopamine agonists by reducing their metabolism and the 'Wearing-off'effects …

Rare, or orphan, diseases are conditions afflicting a small subset of people in a population.
Although these disorders collectively pose significant health care problems, drug companies …

A pharmacophore-based virtual screening methodology was used to discover new catechol-
O-methyltransferase (COMT) inhibitors with interest in Parkinson's disease therapy. To do …

Complementary therapies in neurology Page 2 Page 3 Complementary Therapies in
Neurology AN EVIDENCE-BASED APPROACH Page 4 . Page 5 Complementary Therapies …