Retinal neovascularization, such as that occurring in proliferative diabetic retinopathy and
retinopathy of prematurity, can have serious effects on visual function. By using a mouse …

Diseases of the retina are the leading causes of blindness in the industrialized world. The
recognition that animals develop retinal diseases with similar traits to humans has led to not …

Diabetic retinopathy (DR) has been considered to be a microcirculatory disease of the
retina. However, there is emerging evidence to suggest that retinal neurodegeneration is an …

Purpose Age related macular degeneration (AMD) is the leading cause of irreversible vision
loss in industrialised nations. Based on genetics, as well as proteome analysis of drusen …

The retina is known to have a local renin-angiotensin system (RAS) and dysfunction in the
RAS is often associated with diseases of the retinal vasculature that cause irreversible vision …

Purpose To determine if oral losartan treatment decreases the retinal ganglion cell (RGC)
death caused by experimental intraocular pressure (IOP) elevation in mice. Methods We …

Purpose.: The production of proinflammatory cytokines has been shown to play a critical role
in a variety of retinal vascular diseases. Angiotensin II and VEGF have been implicated in …

The renin–angiotensin system (RAS) is most well-known for its role in regulation and
dysregulation of blood pressure as well as fluid and electrolyte homeostasis. Due to its …

Fenestrations in choriocapillaris act as a window for molecular transports between the retina
and choroid, and is crucial for maintaining visual function. Plasmalemma vesicle-associated …

Impairments in renin-angiotensin-aldosterone system during diabetes mellitus, leading to its
dysfunction, have been known since a decade. Hyperglycemia induces several pathological …