Neovascularization is a hallmark feature of retinopathy of prematurity and diabetic
retinopathy. Type 1 angiotensin receptor blockade reduces neovascularization in …

Retinopathy of prematurity (ROP) is a common retinal disease in preterm babies. To prolong
the lives of preterm babies, high oxygen is provided to mimic the oxygen level in the …

Degeneration of retinal astrocytes precedes hypoxia-driven pathologic neovascularization
and vascular leakage in ischemic retinopathies. However, the molecular events that underlie …

The renin‐angiotensin system (RAS) is a hormone system that has been classically known
as a blood pressure regulator but is becoming well recognized as a proinflammatory …

Angiotensin II type 1 receptor antagonists [ARBs (angiotensin receptor blockers)] are
indicated for BP (blood pressure)-lowering, renal protection and cardioprotection in patients …

Purpose.: To investigate the neuroprotective effect of candesartan, an angiotensin II type 1
receptor (AT1-R) blocker, against the neurotoxicity of the retinal ganglion cells (RGCs) in an …

Diabetic retinopathy (DR) is one of the main causes of vision loss in the working age
population. It is characterized by a progressive deterioration of the retinal microvasculature …

Retinopathy of prematurity (ROP) is a major cause of childhood blindness in the world and is
caused by oxygen-induced damage to the developing retinal vasculature, resulting in …

As our knowledge expands, it is now clear that the renin–angiotensin (Ang) system (RAS)
mediates functions other than regulating blood pressure (BP). The RAS plays a central role …

Retinopathy of prematurity is a devastating vascular disease of premature infants. A number
of studies indicate that retinal function is affected in this disease. Using the rat model of …