From classical methods to generative models: Tackling the unreliability of neuroscientific measures in mental health research

N Haines, H Sullivan-Toole, T Olino - Biological Psychiatry: Cognitive …, 2023 - Elsevier
Advances in computational statistics and corresponding shifts in funding initiatives over the
past few decades have led to a proliferation of neuroscientific measures being developed in …

Poverty, Brain Development, and Mental Health: Progress, Challenges, and Paths Forward

CS Monk, FA Hardi - Annual Review of Developmental …, 2023 - annualreviews.org
Poverty is associated with changes in brain development and elevates the risk for
psychopathology in childhood, adolescence, and adulthood. Although the field is rapidly …

Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine

CH Murray, J Frohlich, CJ Haggarty, I Tare… - …, 2024 - nature.com
Neural complexity correlates with one's level of consciousness. During coma, anesthesia,
and sleep, complexity is reduced. During altered states, including after lysergic acid …

Neural variability in three major psychiatric disorders

W Wei, L Deng, C Qiao, Y Yin, Y Zhang, X Li, H Yu… - Molecular …, 2023 - nature.com
Across the major psychiatric disorders (MPDs), a shared disruption in brain physiology is
suspected. Here we investigate the neural variability at rest, a well-established behavior …

Robust group-but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

M Klingelhöfer-Jens, MR Ehlers, M Kuhn, V Keyaniyan… - Elife, 2022 - elifesciences.org
Here, we follow the call to target measurement reliability as a key prerequisite for individual-
level predictions in translational neuroscience by investigating (1) longitudinal reliability at …

Individual‐Level Prediction of Exposure Therapy Outcome Using Structural and Functional MRI Data in Spider Phobia: A Machine‐Learning Study

AV Chavanne, C Meinke, T Langhammer… - Depression and …, 2023 - Wiley Online Library
Machine‐learning prediction studies have shown potential to inform treatment stratification,
but recent efforts to predict psychotherapy outcomes with clinical routine data have only …

Within-Individual BOLD Signal Variability and its Implications for Task-Based Cognition: A Systematic Review

SN Steinberg, TZ King - Neuropsychology Review, 2023 - Springer
Within-individual blood oxygen level-dependent (BOLD) signal variability, intrinsic moment-
to-moment signal fluctuations within a single individual in specific voxels across a given time …

[HTML][HTML] The biological role of local and global fMRI BOLD signal variability in human brain organization

G Baracchini, Y Zhou, J da Silva Castanheira… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Variability drives the organization and behavior of complex systems, including the human
brain. Understanding the variability of brain signals is thus necessary to broaden our …

[HTML][HTML] Plasma circulating cell-free mitochondrial DNA in social anxiety disorder

D Lindqvist, T Furmark, C Lavebratt, L Ohlsson… - …, 2023 - Elsevier
Objective To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-
mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC). Methods In …

[HTML][HTML] Neurocircuitry of treatment in anxiety disorders

WT Baumel, L Lu, X Huang, AT Drysdale… - Biomarkers in …, 2022 - Elsevier
Background Understanding how treatments change neurobiology is critical to developing
predictors of treatment response. This is especially true for anxiety disorders—the most …