Targeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of
the leading causes of death worldwide. Disbalances of the immune response play an …
the leading causes of death worldwide. Disbalances of the immune response play an …
Amino acid kinetics in the critically ill
Novel tracer and computational approaches have been developed to simultaneously
measure postabsorptive kinetics of multiple amino acids that can be used in critical illness …
measure postabsorptive kinetics of multiple amino acids that can be used in critical illness …
Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma
X Zhang, Y Gao, K Tang, Z Li… - American Journal …, 2024 - journals.physiology.org
Several clinical studies observed a surprising beneficial effect of obesity on enhancing
immunotherapy responsiveness in patients with melanoma, highlighting an as-yet …
immunotherapy responsiveness in patients with melanoma, highlighting an as-yet …
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma
Cancer-related fatigue (CRF) is one of the most common complications in patients with
multiple cancer types and severely affects patients' quality of life. However, there have only …
multiple cancer types and severely affects patients' quality of life. However, there have only …
Metabolic underpinnings of cancer-related fatigue
Cancer-related fatigue (CRF) is one of the most prevalent and detrimental complications of
cancer. Emerging evidence suggests that obesity and insulin resistance are associated with …
cancer. Emerging evidence suggests that obesity and insulin resistance are associated with …
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating …
A Kundu, P Ghosh, B Bishayi - International Immunopharmacology, 2024 - Elsevier
LPS induced sepsis is a complex process involving various immune cells and signaling
molecules. Dysregulation of macrophage polarization and ROS production contributed to …
molecules. Dysregulation of macrophage polarization and ROS production contributed to …
Cuproptosis-Related Biomarkers and Characterization of Immune Infiltration in Sepsis
Y Wang, X Qiu, J Liu, X Liu, J Pan, J Cai… - Journal of …, 2024 - Taylor & Francis
Introduction Sepsis is a worldwide epidemic, with high morbidity and mortality. Cuproptosis
is a form of cell death that is associated with a wide range of diseases. This study aimed to …
is a form of cell death that is associated with a wide range of diseases. This study aimed to …
An in-silico approach to identify bioactive phytochemicals from Houttuynia cordata Thunb. As potential inhibitors of human glutathione reductase
Cellular infections are central to the etiology of various diseases, notably cancer and
malaria. Counteracting cellular oxidative stress via the inhibition of glutathione reductase …
malaria. Counteracting cellular oxidative stress via the inhibition of glutathione reductase …