Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Despite intensive research efforts over the past few decades, the mechanisms underlying
the etiology of sporadic Alzheimer's disease (AD) remain unknown. This fact is of major …

Due to their post-mitotic state, metabolic demands and often large polarised morphology, the
function and survival of neurons is dependent on an efficient cellular waste clearance …

Alzheimer's disease (AD) is the most common form of dementia in the elderly. This brain
neuropathology is characterized by a progressive synaptic dysfunction and neuronal loss …

The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin,
SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved …

Scientific evidence has established several links between metabolic and neurocognitive
dysfunction, and epidemiologic evidence has revealed an increased risk of Alzheimer's …

Excessive proteolytic breakdown of the amyloid precursor protein (APP) to neurotoxic
amyloid β peptides (Aβ) by secretases in the brain is a molecular cause of Alzheimer …

VPS10P (vacuolar protein sorting 10 protein) domain receptors are neuronal sorting
receptors that direct cargo proteins to their destined location in subcellular compartments of …

The formation, function, and plasticity of synapses require dynamic changes in synaptic
receptor composition. Here, we identify the sorting receptor SorCS1 as a key regulator of …

Objective: To characterize the clinical and molecular effect of mutations in the sortilin-related
receptor (SORL1) gene. Methods: We performed whole-exome sequencing in early-onset …